Hannes Lans

Hannes Lans received his Ph.D. from the Erasmus University, Rotterdam, The Netherlands, in 2005. Currently, he is an assistant professor at the Department of Molecular Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands. His research focuses on the mechanism and regulation of nucleotide excision repair in Caenorhabditis elegans and mammals with special emphasis on chromatin remodelling and tissue specificity.

See also this departmental web page.



Selected publications

Mandemaker IK, van Cuijk L, Janssens RC, Lans H, Bezstarosti K, Hoeijmakers JH, Demmers JA, Vermeulen W, Marteijn JA (2017) DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway. Sci Rep. 7:15353 PDF

Jablonski AM, Lamitina T, Liachko NF, Sabatella M, Lu J, Zhang L, Ostrow LW, Gupta P, Wu CY, Doshi S, Mojsilovic-Petrovic J, Lans H, Wang J, Kraemer B, Kalb RG (2015) Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance. J Neuroscience 35:14286-306 PDF

van Cuijk L, van Belle GJ, Turkyilmaz Y, Poulsen SL, Janssens RC, Theil AF, Sabatella M, Lans H, Mailand N, Houtsmuller AB, Vermeulen W, Marteijn JA (2015) SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair Nat Commun 6:7499. doi: 10.1038/ncomms8499 PDF

Lans H, Vermeulen W (2015) Tissue specific response to DNA damage: C. elegans as role model DNA Repair 32:141-148 PDF

Aydin OZ, Vermeulen W, Lans H (2014) ISWI chromatin remodeling complexes in the DNA damage response Cell Cycle 13:3016-3025 PDF

Aydin OZ, Marteijn JA, Ribeiro-Silva C, Rodríguez López A, Wijgers N, Smeenk G, van Attikum H, Poot RA, Vermeulen W, Lans H (2014) Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription Nucleic Acids Res. 42:8473-8485 PDF

Marteijn JA, Lans H, Vermeulen W, Hoeijmakers JH (2014) Understanding nucleotide excision repair and its roles in cancer and ageing Nat Rev Mol Cell Biol 15:465-81 PDF

Lans H, Lindvall JM, Thijssen K, Karambelas AE, Cupac D, Fensgård O, Jansen G, Hoeijmakers JH, Nilsen H, Vermeulen W. (2013) DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals Cell Death Differ 20:1709-18 PDF

Dinant C, Ampatziadis-Michailidis G, Lans H, Tresini M, Lagarou A, Grosbart M, Theil AF, van Cappellen WA, Kimura H, Bartek J, Fousteri M, Houtsmuller AB, Vermeulen W, Marteijn JA (2013) Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage Mol Cell 51:469-79 PDF

Lans H, Hoeijmakers JH (2013) Genome stability, progressive kidney failure and aging Nat Genet 44:836-8 PDF

Lans H, Marteijn JA, Vermeulen W (2012) ATP-dependent chromatin remodeling in the DNA-damage response Epigenetics Chromatin 5:4 PDF

Lans H, Vermeulen W (2011) Nucleotide Excision Repair in Caenorhabditis elegans Mol Biol Int 2011:542795 PDF

Lans H, Marteijn JA, Schumacher B, Hoeijmakers JH, Jansen G, Vermeulen W (2010) Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development PLoS Genet 6:e1000941 PDF

Luijsterburg MS, Dinant C, Lans H, Stap J, Wiernasz E, Lagerwerf S, Warmerdam DO, Lindh M, Brink MC, Dobrucki JW, Aten JA, Fousteri MI, Jansen G, Dantuma NP, Vermeulen W, Mullenders LH, Houtsmuller AB, Verschure PJ, van Driel R (2009) Heterochromatin protein 1 is recruited to various types of DNA damage J Cell Biol 185:577-86

Zhang D, Lans H, Vermeulen W, Lenferink A, Otto C (2008) Quantitative fluorescence correlation spectroscopy reveals a 1000-fold increase in lifetime of protein functionality Biophys J 95:3439-46

Lans H, Hoeijmakers JH (2006) Cell biology: ageing nucleus gets out of shape Nature 440:32-4 PDF