Publications

2017

Marteijn JA, Vermeulen W, Tresini M (2017) Noncanonical ATM Activation and Signaling in Response to Transcription-Blocking DNA Damage Methods Mol Biol 1599:347-361 doi:10.1007/978-1-4939-6955-5_25 PDF

Wienholz F, Vermeulen W, Marteijn JA (2017) Amplification of unscheduled DNA synthesis signal enables fluorescence-based single cell quantification of transcription-coupled nucleotide excision repair Nucleic Acids Res. doi: 10.1093/nar/gkw1360 PDF

2016

Steurer B, Marteijn JA (2016) Traveling Rocky Roads: The consequences of transcription-blocking DNA lesions on RNA polymerase II  J Mol Biol 13. pii: S0022-2836 PDF

Ranes M, Boeing S, Wang Y, Wienholz F, Menoni H, Walker J, Encheva V, Chakravarty P, Mari PO, Stewart A, Giglia-Mari G, Snijders AP, Vermeulen W, Svejstrup JQ (2016) A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair. Nucleic Acids Res. 44:5246-5255 PDF

Tresini M, Marteijn JA, Vermeulen W (2016) Bidirectional coupling of splicing and ATM signaling in response to transcription-blocking DNA damage RNA Biology 25:1-7 PDF

2015

Jablonski AM, Lamitina T, Liachko NF, Sabatella M, Lu J, Zhang L, Ostrow LW, Gupta P, Wu CY, Doshi S, Mojsilovic-Petrovic J, Lans H, Wang J, Kraemer B, Kalb RG (2015) Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance. J Neuroscience 35:14286-306 PDF

Marteijn JA, Hoeijmakers JH, Vermeulen W (2015) Check, Check …Triple Check: Multi-Step DNA Lesion Identification by Nucleotide Excision Repair. Mol Cell 59:885-6 PDF

van Cuijk L, van Belle GJ, Turkyilmaz Y, Poulsen SL, Janssens RC, Theil AF, Sabatella M, Lans H, Mailand N, Houtsmuller AB, Vermeulen W, Marteijn JA (2015) SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair Nat Commun 6:7499. doi: 10.1038/ncomms8499 PDF

Tresini M, Warmerdam DO, Kolovos P, Snijder L, Vrouwe MG, Demmers JA, van IJcken WF, Grosveld FG, Medema RH, Hoeijmakers JH, Mullenders LH, Vermeulen W, Marteijn JA (2015) The core spliceosome as target and effector of non-canonical ATM signalling Nature 523:53-58 PDF

Lans H, Vermeulen W (2015) Tissue specific response to DNA damage: C. elegans as role model DNA Repair 32:141-148 PDF

2014

Gourdin AM, van Cuijk L, Tresini M, Luijsterburg MS, Nigg AL, Giglia-Mari G, Houtsmuller AB, Vermeulen W, Marteijn JA (2014) Differential binding kinetics of replication protein A during replication and the pre- and post-incision steps of nucleotide excision repair DNA Repair 24:46-56 PDF

Aydin OZ, Vermeulen W, Lans H (2014) ISWI chromatin remodeling complexes in the DNA damage response Cell Cycle 13:3016-3025 PDF

van Cuijk L, Vermeulen W, Marteijn JA (2014) Ubiquitin at work: The ubiquitous regulation of the damage recognition step of NER Exp Cell Res 329:101-9 PDF

Theil AF, Hoeijmakers JH, Vermeulen W (2014) TTDA: Big impact of a small protein Exp Cell Res 329:61-8 PDF

Aydin OZ, Marteijn JA, Ribeiro-Silva C, Rodríguez López A, Wijgers N, Smeenk G, van Attikum H, Poot RA, Vermeulen W, Lans H (2014) Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription Nucleic Acids Res. 42:8473-8485 PDF

Swagemakers SM, Jaspers NG, Raams A, Heijsman D, Vermeulen W, Troelstra C, Kremer A, Lincoln SE, Tearle R, Hoeijmakers JH, van der Spek PJ (2014) Pollitt syndrome patients carry mutation in TTDN1 Meta Gene 2:616-8 PDF

Marteijn JA, Lans H, Vermeulen W, Hoeijmakers JH (2014) Understanding nucleotide excision repair and its roles in cancer and ageing Nat Rev Mol Cell Biol 15:465-81 PDF

Mandemaker I, Vermeulen W, Marteijn J (2014) Role of chromatin remodeling during the transcriptional restart upon DNA damage Nucleus 5:203-10 PDF

2013

Mourgues S, Gautier V, Lagarou A, Bordier C, Mourcet A, Slingerland J, Kaddoum L, Coin F,Vermeulen W, Gonzales de Peredo A, Monsarrat B, Mari PO, Giglia-Mari G (2013) ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair. Proc Natl Acad Sci U S A. 110:17927-32 PDF

Lans H, Lindvall JM, Thijssen K, Karambelas AE, Cupac D, Fensgård O, Jansen G, Hoeijmakers JH, Nilsen H, Vermeulen W. (2013) DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals Cell Death Differ 20:1709-18 PDF

Dinant C, Ampatziadis-Michailidis G, Lans H, Tresini M, Lagarou A, Grosbart M, Theil AF, van Cappellen WA, Kimura H, Bartek J, Fousteri M, Houtsmuller AB, Vermeulen W, Marteijn JA (2013) Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage Mol Cell 51:469-79 PDF

Vermeulen W, Fousteri M (2013) Mammalian transcription-coupled excision repair Cold Spring Harb Perspect Biol 5(8):a012625 PDF

Bergink S, Theil AF, Toussaint W, De Cuyper IM, Kulu DI, Clapes T, van der Linden R, Demmers JA, Mul EP, van Alphen FP, Marteijn JA, van Gent T, Maas A, Robin C, Philipsen S, Vermeulen W, Mitchell JR, Gutiérrez L (2013) Erythropoietic defect associated with reduced cell proliferation in mice lacking the 26S proteasome shuttling factor Rad23b Mol Cell Biol 33:3879-92

Schwertman P, Vermeulen W, Marteijn JA (2013) UVSSA and USP7, a new couple in transcription-coupled DNA repair Chromosoma 122:275-84 PDF

Poulsen SL, Hansen RK, Wagner SA, van Cuijk L, van Belle GJ, Streicher W, Wikström M, Choudhary C, Houtsmuller AB, Marteijn JA, Bekker-Jensen S, Mailand N (2013) RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response J Cell Biol 201:797-807 PDF

Schwertman P, Bezstarosti K, Laffeber C, Vermeulen W, Demmers JA, Marteijn JA (2013) An immunoaffinity purification method for the proteomic analysis of ubiquitinated protein complexes Anal Biochem 440:227-36 PDF

Kouzine F, Wojtowicz D, Yamane A, Resch W, Kieffer-Kwon KR, Bandle R, Nelson S, Nakahashi H, Awasthi P, Feigenbaum L, Menoni H, Hoeijmakers J, Vermeulen W, Ge H, Przytycka TM, Levens D, Casellas R (2013) Global regulation of promoter melting in naive lymphocytes Cell 153:988-99

Theil AF, Nonnekens J, Steurer B, Mari PO, de Wit J, Lemaitre C, Marteijn JA, Raams A, Maas A, Vermeij M, Essers J, Hoeijmakers JH, Giglia-Mari G, Vermeulen W (2013) Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality PLoS Genet 9(4):e1003431 PDF

Campalans A, Kortulewski T, Amouroux R, Menoni H, Vermeulen W, Radicella JP (2013) Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair Nucleic Acids Res 41:3115-29 PDF

Smeenk G, Wiegant WW, Marteijn JA, Luijsterburg MS, Sroczynski N, Costelloe T, Romeijn RJ, Pastink A, Mailand N, Vermeulen W, van Attikum H (2013) Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling J Cell Sci 126:889-903 PDF

2012

Menoni H, Hoeijmakers JH, Vermeulen W (2012) Nucleotide excision repair-initiating proteins bind to oxidative DNA lesions in vivo J Cell Biol. 199:1037-46 PDF

Pines A, Vrouwe MG, Marteijn JA, Typas D, Luijsterburg MS, Cansoy M, Hensbergen P, Deelder A, de Groot A, Matsumoto S, Sugasawa K, Thoma N, Vermeulen W, Vrieling H, Mullenders L (2012) PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1 J Cell Biol 199:235-49

Mattiroli F, Vissers JH, van Dijk WJ, Ikpa P, Citterio E, Vermeulen W, Marteijn JA, Sixma TK (2012) RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling Cell 150:1182-95

Godon C, Mourgues S, Nonnekens J, Mourcet A, Coin F, Vermeulen W, Mari PO, Giglia-Mari G (2012) Generation of DNA single-strand displacement by compromised nucleotide excision repair EMBO J 31:3550-63

Kleppa L, Mari PO, Larsen E, Lien GF, Godon C, Theil AF, Nesse GJ, Wiksen H, Vermeulen W, Giglia-Mari G, Klungland A (2012) Kinetics of endogenous mouse FEN1 in base excision repair Nucleic Acids Res 40:9044-59

Lans H, Hoeijmakers JH (2013) Genome stability, progressive kidney failure and aging Nat Genet 44:836-8 PDF

Schwertman P, Lagarou A, Dekkers DH, Raams A, van der Hoek AC, Laffeber C, Hoeijmakers JH, Demmers JA, Fousteri M, Vermeulen W, Marteijn JA (2012) UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair Nat Genet 44:598-602 PDF

Bergink S, Toussaint W, Luijsterburg MS, Dinant C, Alekseev S, Hoeijmakers JH, Dantuma NP, Houtsmuller AB, Vermeulen W (2012) Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex J Cell Biol 196:681-8 PDF

Lans H, Marteijn JA, Vermeulen W (2012) ATP-dependent chromatin remodeling in the DNA-damage response Epigenetics Chromatin 5:4 PDF

2011

Lans H, Vermeulen W (2011) Nucleotide Excision Repair in Caenorhabditis elegans Mol Biol Int 2011:542795 PDF

Theil AF, Nonnekens J, Wijgers N, Vermeulen W, Giglia-Mari G (2011) Slowly progressing nucleotide excision repair in trichothiodystrophy group A patient fibroblasts Mol Cell Biol 31:3630-8 PDF

Vermeulen W (2011) Dynamics of mammalian NER proteins DNA Repair 10:760-71 PDF

Giglia-Mari G, Zotter A, Vermeulen W (2011) DNA damage response Cold Spring Harb Perspect Biol 3:a000745 PDF

Overmeer RM, Gourdin AM, Giglia-Mari A, Kool H, Houtsmuller AB, Siegal G, Fousteri MI, Mullenders LH, Vermeulen W (2011) Replication factor C recruits DNA polymerase delta to sites of nucleotide excision repair but is not required for PCNA recruitment Mol Cell Biol 30:4828-39 PDF

2010

Anindya R, Mari PO, Kristensen U, Kool H, Giglia-Mari G, Mullenders LH, Fousteri M, Vermeulen W, Egly JM, Svejstrup JQ (2010) A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair Mol Cell 38:637-48

Lans H, Marteijn JA, Schumacher B, Hoeijmakers JH, Jansen G, Vermeulen W (2010) Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development PLoS Genet 6:e1000941 PDF

Luijsterburg MS, von Bornstaedt G, Gourdin AM, Politi AZ, Moné MJ, Warmerdam DO, Goedhart J, Vermeulen W, van Driel R, Höfer T (2010) Stochastic and reversible assembly of a multiprotein DNA repair complex ensures accurate target site recognition and efficient repair J Cell Biol 189:445-63

Mari PO, Verbiest V, Sabbioneda S, Gourdin AM, Wijgers N, Dinant C, Lehmann AR, Vermeulen W, Giglia-Mari G (2010) Influence of the live cell DNA marker DRAQ5 on chromatin-associated processes DNA Repair 9:848-55

Ahmad A, Enzlin JH, Bhagwat NR, Wijgers N, Raams A, Appledoorn E, Theil AF, J Hoeijmakers JH, Vermeulen W, J Jaspers NG, Schärer OD, Niedernhofer LJ (2010) Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients PLoS Genet 6:e1000871

2009

Gourdin AM, Vermeulen W (2009) Focus on foci: DNA damage foci, structures without a function? Cell Cycle 8:3812-3

Giglia-Mari G, Theil AF, Mari PO, Mourgues S, Nonnekens J, Andrieux LO, de Wit J, Miquel C, Wijgers N, Maas A, Fousteri M, Hoeijmakers JH, Vermeulen W (2009) Differentiation driven changes in the dynamic organization of Basal transcription initiation PLoS Biol 7:e1000220 PDF

Marteijn JA, Bekker-Jensen S, Mailand N, Lans H, Schwertman P, Gourdin AM, Dantuma NP, Lukas J, Vermeulen W (2009) Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response J Cell Biol 186:835-47 PDF

Luijsterburg MS, Dinant C, Lans H, Stap J, Wiernasz E, Lagerwerf S, Warmerdam DO, Lindh M, Brink MC, Dobrucki JW, Aten JA, Fousteri MI, Jansen G, Dantuma NP, Vermeulen W, Mullenders LH, Houtsmuller AB, Verschure PJ, van Driel R (2009) Heterochromatin protein 1 is recruited to various types of DNA damage J Cell Biol 185:577-86

Dinant C, Luijsterburg MS, Höfer T, von Bornstaedt G, Vermeulen W, Houtsmuller AB, van Driel R (2009) Assembly of multiprotein complexes that control genome function J Cell Biol 2009 185:21-6

Nishi R, Alekseev S, Dinant C, Hoogstraten D, Houtsmuller AB, Hoeijmakers JH, Vermeulen W, Hanaoka F, Sugasawa K (2009) UV-DDB-dependent regulation of nucleotide excision repair kinetics in living cells DNA Repair 8:767-76

Staresincic L, Fagbemi AF, Enzlin JH, Gourdin AM, Wijgers N, Dunand-Sauthier I, Giglia-Mari G, Clarkson SG, Vermeulen W, Schärer OD (2009) Coordination of dual incision and repair synthesis in human nucleotide excision repair EMBO J 28:1111-20

Solimando L, Luijsterburg MS, Vecchio L, Vermeulen W, van Driel R, Fakan S (2009) Spatial organization of nucleotide excision repair proteins after UV-induced DNA damage in the human cell nucleus J Cell Sci 122:83-91

2008

Dinant C, Houtsmuller AB, Vermeulen W (2008) Chromatin structure and DNA damage repair Epigenetics Chromatin 1:9 PDF

Alekseev S, Luijsterburg MS, Pines A, Geverts B, Mari PO, Giglia-Mari G, Lans H, Houtsmuller AB, Mullenders LH, Hoeijmakers JH, Vermeulen W (2008) Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage Mol Cell Biol 28:7402-13 PDF

Sabbioneda S, Gourdin AM, Green CM, Zotter A, Giglia-Mari G, Houtsmuller A, Vermeulen W, Lehmann AR (2008) Effect of proliferating cell nuclear antigen ubiquitination and chromatin structure on the dynamic properties of the Y-family DNA polymerases Mol Biol Cell 19:5193-202

Hoogstraten D, Bergink S, Ng JM, Verbiest VH, Luijsterburg MS, Geverts B, Raams A, Dinant C, Hoeijmakers JH, Vermeulen W, Houtsmuller AB (2008) Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC J Cell Sci 121:2850-9 PDF

Dinant C, van Royen ME, Vermeulen W, Houtsmuller AB (2008) Fluorescence resonance energy transfer of GFP and YFP by spectral imaging and quantitative acceptor photobleaching J Microsc 231:97-104

Zhang D, Lans H, Vermeulen W, Lenferink A, Otto C (2008) Quantitative fluorescence correlation spectroscopy reveals a 1000-fold increase in lifetime of protein functionality Biophys J 95:3439-46

Roche Y, Zhang D, Segers-Nolten GM, Vermeulen W, Wyman C, Sugasawa K, Hoeijmakers J, Otto C (2008) Fluorescence correlation spectroscopy of the binding of nucleotide excision repair protein XPC-hHr23B with DNA substrates J Fluoresc 18:987-95

Maltseva EA, Rechkunova NI, Petruseva IO, Vermeulen W, Schärer OD, Lavrik OI (2008) Crosslinking of nucleotide excision repair proteins with DNA containing photoreactive damages

Bioorg Chem 36:77-84

2007

Nicassio F, Corrado N, Vissers JH, Areces LB, Bergink S, Marteijn JA, Geverts B, Houtsmuller AB, Vermeulen W, Di Fiore PP, Citterio E (2007) Human USP3 is a chromatin modifier required for S phase progression and genome stability Curr Biol 17:1972-7

Dinant C, de Jager M, Essers J, van Cappellen WA, Kanaar R, Houtsmuller AB, Vermeulen W (2007) Activation of multiple DNA repair pathways by sub-nuclear damage induction methods J Cell Sci 120:2731-40

Luijsterburg MS, Goedhart J, Moser J, Kool H, Geverts B, Houtsmuller AB, Mullenders LH, Vermeulen W, van Driel R (2007) Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC J Cell Sci 120:2706-16

Bergink S, Jaspers NG, Vermeulen W (2007) Regulation of UV-induced DNA damage response by ubiquitylation DNA Repair 6:1231-42

Jaspers NG, Raams A, Silengo MC, Wijgers N, Niedernhofer LJ, Robinson AR, Giglia-Mari G, Hoogstraten D, Kleijer WJ, Hoeijmakers JH, Vermeulen W (2007) First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure Am J Hum Genet 80:457-66 PDF

2006

Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appeldoorn E, Odijk H, Oostendorp R, Ahmad A, van Leeuwen W, Theil AF, Vermeulen W, van der Horst GT, Meinecke P, Kleijer WJ, Vijg J, Jaspers NG, Hoeijmakers JH (2006) A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis Nature 444:1038-43 PDF

Zotter A, Luijsterburg MS, Warmerdam DO, Ibrahim S, Nigg A, van Cappellen WA, Hoeijmakers JH, van Driel R, Vermeulen W, Houtsmuller AB (2006) Recruitment of the nucleotide excision repair endonuclease XPG to sites of UV-induced dna damage depends on functional TFIIH Mol Cell Biol 26:8868-79

Fousteri M, Vermeulen W, van Zeeland AA, Mullenders LH (2006) Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo Mol Cell 23:471-82

Andressoo JO, Mitchell JR, de Wit J, Hoogstraten D, Volker M, Toussaint W, Speksnijder E, Beems RB, van Steeg H, Jans J, de Zeeuw CI, Jaspers NG, Raams A, Lehmann AR, Vermeulen W, Hoeijmakers JH, van der Horst GT (2006) An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria Cancer Cell 10:121-32

Bergink S, Severijnen LA, Wijgers N, Sugasawa K, Yousaf H, Kros JM, van Swieten J, Oostra BA, Hoeijmakers JH, Vermeulen W, Willemsen R (2006) The DNA repair-ubiquitin-associated HR23 proteins are constituents of neuronal inclusions in specific neurodegenerative disorders without hampering DNA repair Neurobiol Dis 23:708-16

Bergink S, Salomons FA, Hoogstraten D, Groothuis TA, de Waard H, Wu J, Yuan L, Citterio E, Houtsmuller AB, Neefjes J, Hoeijmakers JH, Vermeulen W, Dantuma NP (2006) DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A Genes Dev 20:1343-52 PDF

Giglia-Mari G, Miquel C, Theil AF, Mari PO, Hoogstraten D, Ng JM, Dinant C, Hoeijmakers JH, Vermeulen W (2006) Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells PLoS Biol 4:e156 PDF

Lans H, Hoeijmakers JH (2006) Cell biology: ageing nucleus gets out of shape Nature 440:32-4 PDF

Essers J, Vermeulen W, Houtsmuller AB (2006) DNA damage repair: anytime, anywhere? Curr Opin Cell Biol 18:240-6

Maltseva EA, Rechkunova NI, Petruseva IO, Silnikov VN, Vermeulen W, Lavrik OI (2006) Interaction of nucleotide excision repair factors RPA and XPA with DNA containing bulky photoreactive groups imitating damages Biochemistry 71:270-8

2005

Essers J, Theil AF, Baldeyron C, van Cappellen WA, Houtsmuller AB, Kanaar R, Vermeulen W (2005) Nuclear dynamics of PCNA in DNA replication and repair Mol Cell Biol 25:9350-9

Politi A, Moné MJ, Houtsmuller AB, Hoogstraten D, Vermeulen W, Heinrich R, van Driel R (2005) Mathematical modeling of nucleotide excision repair reveals efficiency of sequential assembly strategies Mol Cell 19:679-90

Essers J, van Cappellen WA, Theil AF, van Drunen E, Jaspers NG, Hoeijmakers JH, Wyman C, Vermeulen W, Kanaar R (2005) Dynamics of relative chromosome position during the cell cycle Mol Biol Cell 16:769-75

Beerens N, Hoeijmakers JH, Kanaar R, Vermeulen W, Wyman C (2005) The CSB protein actively wraps DNA J Biol Chem 280:4722-9

2004

Thorel F, Constantinou A, Dunand-Sauthier I, Nouspikel T, Lalle P, Raams A, Jaspers NG, Vermeulen W, Shivji MK, Wood RD, Clarkson SG (2004) Definition of a short region of XPG necessary for TFIIH interaction and stable recruitment to sites of UV damage Mol Cell Biol 24:10670-80

Coin F, Auriol J, Tapias A, Clivio P, Vermeulen W, Egly JM (2004) Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity EMBO J 23:4835-46

Moné MJ, Bernas T, Dinant C, Goedvree FA, Manders EM, Volker M, Houtsmuller AB, Hoeijmakers JH, Vermeulen W, van Driel R (2004) In vivo dynamics of chromatin-associated complex formation in mammalian nucleotide excision repair Proc Natl Acad Sci U S A 101:15933-7

Okuda Y, Nishi R, Ng JM, Vermeulen W, van der Horst GT, Mori T, Hoeijmakers JH, Hanaoka F, Sugasawa K (2004) Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex DNA Repair 3:1285-95

van den Boom V, Citterio E, Hoogstraten D, Zotter A, Egly JM, van Cappellen WA, Hoeijmakers JH, Houtsmuller AB, Vermeulen W (2004) DNA damage stabilizes interaction of CSB with the transcription elongation machinery J Cell Biol 166:27-36

Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (2004) A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A Nat Genet 36:714-9 PDF

2003

Rademakers S, Volker M, Hoogstraten D, Nigg AL, Moné MJ, Van Zeeland AA, Hoeijmakers JH, Houtsmuller AB, Vermeulen W (2003) Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions Mol Cell Biol 23:5755-67

Ng JM, Vermeulen W, van der Horst GT, Bergink S, Sugasawa K, Vrieling H, Hoeijmakers JH (2003) A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein Genes Dev 17:1630-45

2002

Vermeulen W, Houtsmuller AB (2002) The transcription cycle in vivo A blind watchmaker at work Mol Cell 10:1264-6

Hoogstraten D, Nigg AL, Heath H, Mullenders LH, van Driel R, Hoeijmakers JH, Vermeulen W, Houtsmuller AB (2002) Rapid switching of TFIIH between RNA polymerase I and II transcription and DNA repair in vivo Mol Cell 10:1163-74

Segers-Nolten GM, Wyman C, Wijgers N, Vermeulen W, Lenferink AT, Hoeijmakers JH, Greve J, Otto C (2002) Scanning confocal fluorescence microscopy for single molecule analysis of nucleotide excision repair complexes Nucleic Acids Res 30:4720-7

van den Boom V, Jaspers NG, Vermeulen W (2002) When machines get stuck–obstructed RNA polymerase II: displacement, degradation or suicide Bioessays 24:780-4

Essers J, Houtsmuller AB, van Veelen L, Paulusma C, Nigg AL, Pastink A, Vermeulen W, Hoeijmakers JH, Kanaar R (2002) Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage EMBO J 21:2030-7

2001

Volker M, Moné MJ, Karmakar P, van Hoffen A, Schul W, Vermeulen W, Hoeijmakers JH, van Driel R, van Zeeland AA, Mullenders LH (2001) Sequential assembly of the nucleotide excision repair factors in vivo Mol Cell 8:213-24

Akhmanova A, Hoogenraad CC, Drabek K, Stepanova T, Dortland B, Verkerk T, Vermeulen W, Burgering BM, De Zeeuw CI, Grosveld F, Galjart N (2001) Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts Cell 104:923-35

Vermeulen W, Rademakers S, Jaspers NG, Appeldoorn E, Raams A, Klein B, Kleijer WJ, Hansen LK, Hoeijmakers JH (2001) A temperature-sensitive disorder in basal transcription and DNA repair in humans Nat Genet 27:299-303

Houtsmuller AB, Vermeulen W (2001) Macromolecular dynamics in living cell nuclei revealed by fluorescence redistribution after photobleaching Histochem Cell Biol 115:13-21

2000

Seroz T, Winkler GS, Auriol J, Verhage RA, Vermeulen W, Smit B, Brouwer J, Eker AP, Weeda G, Egly JM, Hoeijmakers JH (2000) Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases Nucleic Acids Res 28:4506-13

Vermeulen W, Bergmann E, Auriol J, Rademakers S, Frit P, Appeldoorn E, Hoeijmakers JH, Egly JM (2000) Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder Nat Genet 26:307-13

Citterio E, Van Den Boom V, Schnitzler G, Kanaar R, Bonte E, Kingston RE, Hoeijmakers JH, Vermeulen W (2000) ATP-dependent chromatin remodeling by the Cockayne syndrome B DNA repair-transcription-coupling factor Mol Cell Biol 20:7643-53

Nakatsu Y, Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, Yeo JP, Khaw MC, Saijo M, Kodo N, Matsuda T, Hoeijmakers JH, Tanaka K (2000) XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription J Biol Chem 275:34931-7

Citterio E, Vermeulen W, Hoeijmakers JH (2000) Transcriptional healing Cell 101:447-50

Winkler GS, Araújo SJ, Fiedler U, Vermeulen W, Coin F, Egly JM, Hoeijmakers JH, Wood RD, Timmers HT, Weeda G (2000) TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair J Biol Chem 275:4258-66

1999

Houtsmuller AB, Rademakers S, Nigg AL, Hoogstraten D, Hoeijmakers JH, Vermeulen W (1999) Action of DNA repair endonuclease ERCC1/XPF in living cells Science 284:958-61

1998

Weeda G, de Boer J, Donker I, de Wit J, Winkler SB, van der Horst GT, Vermeulen W, Bootsma D, Hoeijmakers JH (1998) Molecular basis of DNA repair mechanisms and syndromes Recent Results Cancer Res 154:147-55

Citterio E, Rademakers S, van der Horst GT, van Gool AJ, Hoeijmakers JH, Vermeulen W (1998) Biochemical and biological characterization of wild-type and ATPase-deficient Cockayne syndrome B repair protein J Biol Chem 273:11844-51

Winkler GS, Vermeulen W, Coin F, Egly JM, Hoeijmakers JH, Weeda G (1998) Affinity purification of human DNA repair/transcription factor TFIIH using epitope-tagged xeroderma pigmentosum B protein J Biol Chem 273:1092-8

1997

Vichi P, Coin F, Renaud JP, Vermeulen W, Hoeijmakers JH, Moras D, Egly JM (1997) Cisplatin- and UV-damaged DNA lure the basal transcription factor TFIID/TBP EMBO J 16:7444-56

van Gool AJ, Citterio E, Rademakers S, van Os R, Vermeulen W, Constantinou A, Egly JM, Bootsma D, Hoeijmakers JH (1997) The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex EMBO J 16:5955-65

Weeda G, Rossignol M, Fraser RA, Winkler GS, Vermeulen W, van ’t Veer LJ, Ma L, Hoeijmakers JH, Egly JM (1997) The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor Nucleic Acids Res 25:2274-83

Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (1997) Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH EMBO J 16:1093-102

Vermeulen W, de Boer J, Citterio E, van Gool AJ, van der Horst GT, Jaspers NG, de Laat WL, Sijbers AM, van der Spek PJ, Sugasawa K, Weeda G, Winkler GS, Bootsma D, Egly JM, Hoeijmakers JH (1997) Mammalian nucleotide excision repair and syndromes Biochem Soc Trans 25:309-15

Weeda G, Eveno E, Donker I, Vermeulen W, Chevallier-Lagente O, Taïeb A, Stary A, Hoeijmakers JH, Mezzina M, Sarasin A (1997) A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy Am J Hum Genet 60:320-9

1996

Moriwaki S, Stefanini M, Lehmann AR, Hoeijmakers JH, Robbins JH, Rapin I, Botta E, Tanganelli B, Vermeulen W, Broughton BC, Kraemer KH (1996) DNA repair and ultraviolet mutagenesis in cells from a new patient with xeroderma pigmentosum group G and cockayne syndrome resemble xeroderma pigmentosum cells J Invest Dermatol 107:647-53

Hwang JR, Moncollin V, Vermeulen W, Seroz T, van Vuuren H, Hoeijmakers JH, Egly JM (1996) A 3′ –> 5′ XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription J Biol Chem 271:15898-904

Wang XW, Vermeulen W, Coursen JD, Gibson M, Lupold SE, Forrester K, Xu G, Elmore L, Yeh H, Hoeijmakers JH, Harris CC (1996) The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway Genes Dev 10:1219-32

Hoeijmakers JH, Egly JM, Vermeulen W (1996) TFIIH: a key component in multiple DNA transactions Curr Opin Genet Dev 6:26-33

1995

Wang XW, Gibson MK, Vermeulen W, Yeh H, Forrester K, Stürzbecher HW, Hoeijmakers JH, Harris CC (1995) Abrogation of p53-induced apoptosis by the hepatitis B virus X gene Cancer Res 55:6012-6

Carreau M, Eveno E, Quilliet X, Chevalier-Lagente O, Benoit A, Tanganelli B, Stefanini M, Vermeulen W, Hoeijmakers JH, Sarasin A, et al (1995) Development of a new easy complementation assay for DNA repair deficient human syndromes using cloned repair genes Carcinogenesis 16:1003-9

Bootsma D, Weeda G, Vermeulen W, van Vuuren H, Troelstra C, van der Spek P, Hoeijmakers J (1995) Nucleotide excision repair syndromes: molecular basis and clinical symptoms Philos Trans R Soc Lond B Biol Sci 347:75-81

Broughton BC, Thompson AF, Harcourt SA, Vermeulen W, Hoeijmakers JH, Botta E, Stefanini M, King MD, Weber CA, Cole J, et al (1995) Molecular and cellular analysis of the DNA repair defect in a patient in xeroderma pigmentosum complementation group D who has the clinical features of xeroderma pigmentosum and Cockayne syndrome Am J Hum Genet 56:167-74

1994

Roy R, Adamczewski JP, Seroz T, Vermeulen W, Tassan JP, Schaeffer L, Nigg EA, Hoeijmakers JH, Egly JM (1994) The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor Cell 79:1093-101

Mezzina M, Eveno E, Chevallier-Lagente O, Benoit A, Carreau M, Vermeulen W, Hoeijmakers JH, Stefanini M, Lehmann AR, Weber CA, et al (1994) Correction by the ERCC2 gene of UV sensitivity and repair deficiency phenotype in a subset of trichothiodystrophy cells Carcinogenesis 15:1493-8

Keeney S, Eker AP, Brody T, Vermeulen W, Bootsma D, Hoeijmakers JH, Linn S (1994) Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein Proc Natl Acad Sci U S A 91:4053-6

van Vuuren AJ, Vermeulen W, Ma L, Weeda G, Appeldoorn E, Jaspers NG, van der Eb AJ, Bootsma D, Hoeijmakers JH, Humbert S, et al (1994) Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH) EMBO J 13:1645-53

Roy R, Schaeffer L, Humbert S, Vermeulen W, Weeda G, Egly JM (1994) The DNA-dependent ATPase activity associated with the class II basic transcription factor BTF2/TFIIH J Biol Chem 269:9826-32

Vermeulen W, Scott RJ, Rodgers S, Müller HJ, Cole J, Arlett CF, Kleijer WJ, Bootsma D, Hoeijmakers JH, Weeda G (1994) Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3 Am J Hum Genet 54:191-200

Vermeulen W, van Vuuren AJ, Chipoulet M, Schaeffer L, Appeldoorn E, Weeda G, Jaspers NG, Priestley A, Arlett CF, Lehmann AR, et al (1994) Three unusual repair deficiencies associated with transcription factor BTF2(TFIIH): evidence for the existence of a transcription syndrome Cold Spring Harb Symp Quant Biol 59:317-29

1993

Stefanini M, Vermeulen W, Weeda G, Giliani S, Nardo T, Mezzina M, Sarasin A, Harper JI, Arlett CF, Hoeijmakers JH, et al (1993) A new nucleotide-excision-repair gene associated with the disorder trichothiodystrophy Am J Hum Genet 53:817-21

Vermeulen W, Jaeken J, Jaspers NG, Bootsma D, Hoeijmakers JH (1993) Xeroderma pigmentosum complementation group G associated with Cockayne syndrome Am J Hum Genet 53:185-92

Molinete M, Vermeulen W, Bürkle A, Ménissier-de Murcia J, Küpper JH, Hoeijmakers JH, de Murcia G (1993) Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells EMBO J 12:2109-17

Schaeffer L, Roy R, Humbert S, Moncollin V, Vermeulen W, Hoeijmakers JH, Chambon P, Egly JM (1993) DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor Science 260:58-63

1992

Troelstra C, van Gool A, de Wit J, Vermeulen W, Bootsma D, Hoeijmakers JH (1992) ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne’s syndrome and preferential repair of active genes Cell 71:939-53

Eker AP, Vermeulen W, Miura N, Tanaka K, Jaspers NG, Hoeijmakers JH, Bootsma D (1992) Xeroderma pigmentosum group A correcting protein from calf thymus Mutat Res 274:211-24

1991

Vermeulen W, Stefanini M, Giliani S, Hoeijmakers JH, Bootsma D (1991) Xeroderma pigmentosum complementation group H falls into complementation group D Mutat Res 255:201-8

1990

Weeda G, van Ham RC, Vermeulen W, Bootsma D, van der Eb AJ, Hoeijmakers JH (1990) A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne’s syndrome Cell 62:777-91

Roza L, Vermeulen W, Bergen Henegouwen JB, Eker AP, Jaspers NG, Lohman PH, Hoeijmakers JH (1990) Effects of microinjected photoreactivating enzyme on thymine dimer removal and DNA repair synthesis in normal human and xeroderma pigmentosum fibroblasts Cancer Res 50:1905-10

1989

van Duin M, Vredeveldt G, Mayne LV, Odijk H, Vermeulen W, Klein B, Weeda G, Hoeijmakers JH, Bootsma D, Westerveld A (1989) The cloned human DNA excision repair gene ERCC-1 fails to correct xeroderma pigmentosum complementation groups A through I Mutat Res 217:83-92

1986

Zwetsloot JC, Barbeiro AP, Vermeulen W, Arthur HM, Hoeijmakers JH, Backendorf C (1986) Microinjection of Escherichia coli UvrA, B, C and D proteins into fibroblasts of xeroderma pigmentosum complementation groups A and C does not result in restoration of UV-induced unscheduled DNA synthesis Mutat Res 166:89-98

Vermeulen W, Osseweijer P, de Jonge AJ, Hoeijmakers JH (1986) Transient correction of excision repair defects in fibroblasts of 9 xeroderma pigmentosum complementation groups by microinjection of crude human cell extracts Mutat Res 165:199-206

Zwetsloot JC, Hoeymakers JH, Vermeulen W, Eker AP, Bootsma D (1986) Unscheduled DNA synthesis in xeroderma pigmentosum cells after microinjection of yeast photoreactivating enzyme Mutat Res 165:109-15

1985

Zwetsloot JC, Vermeulen W, Hoeijmakers JH, Yasui A, Eker AP, Bootsma D (1985) Microinjected photoreactivating enzymes from Anacystis and Saccharomyces monomerize dimers in chromatin of human cells Mutat Res 146:71-7

de Jonge AJ, Vermeulen W, Keijzer W, Hoeijmakers JH, Bootsma D (1985) Microinjection of Micrococcus luteus UV-endonuclease restores UV-induced unscheduled DNA synthesis in cells of 9 xeroderma pigmentosum complementation groups Mutat Res 150:99-105

1983

de Jonge AJ, Vermeulen W, Klein B, Hoeijmakers JH (1983) Microinjection of human cell extracts corrects xeroderma pigmentosum defect EMBO J 2:637-41